Nervonic acid reduces the cognitive and neurological disturbances induced by combined doses of D‐galactose/<scp>AlCl₃</scp> in mice

Nervonic acid (NA) is a kind of ultra-long-chain monounsaturated fatty acid, which can repair nerve cell damage caused by oxidative stress. Alzheimer's disease (AD) nervous system and often accompanied the decline learning memory capacity. In this study, combined dose D-galactose/AlCl3 was used to establish mouse model AD. Meanwhile, mice were treated with different doses NA (10.95 43.93 mg/kg). The results showed that delayed locomotion ability D-galactose/AlCl3, increased activity total superoxide dismutase, catalase, glutathione peroxidase, reduced content malondialdehyde in vivo. Besides, levels interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), aspartate aminotransferase, alanine 5-hydroxytryptamine, dopamine, γ-aminobutyric alleviated morphology induced hippocampus liver tissue. Furthermore, intervention upregulated expression PI3K, AKT, mTOR genes downregulated TNF-α, IL-6, IL-1β genes. Therefore, we speculate could be an effective way improving cognitive impairment through activation PI3K signaling pathway. These suggest has potential developed as antioxidant drug for prevention early therapy